Description
What is semaglutide?
Semaglutide is used for weight loss, to lower blood sugar levels in type 2 diabetes, and to reduce the risk of major cardiovascular events and chronic kidney disease in certain adult patients.
Semaglutide is a GLP-1 agonist that works by reducing appetite, delaying gastric emptying, increasing insulin release, and lowering the amount of glucagon released.
Semaglutide brand names are Ozempic, Rybelus, and Wegovy , which are made by Novo Nordisk, and are FDA-approved for different conditions. Semaglutide FDA approval was first granted on December 5, 2017, for the brand Ozempic.
What is semaglutide used for?
Wegovy (semaglutide) for weight loss
- Wegovy (semaglutide) is used for weight loss and weight maintenance in patients 12 years and older with obesity
- Used for reducing major cardiovascular event risks (such as heart attack, stroke, or death) in adults with type 2 diabetes with known heart disease
- Injection is given 1 time a week under the skin of the stomach (belly), the thigh, or the upper arm, using an autoinjector (pen)
- This injection should be used in addition to a reduced-calorie diet and increased physical activity
Ozempic (semaglutide) injection
- Ozempic is used to treat type 2 diabetes in adults to help control blood sugar levels used together with diet and exercise,
- Used for reducing major cardiovascular event risks (such as heart attack, stroke, or death) in adults with type 2 diabetes with known heart disease
- Used to reduce the risk of kidney function decline, kidney failure, and death due to cardiovascular disease, in adults with chronic kidney disease (CKD) and type 2 diabetes
- Injection is given 1 time a week under the skin of the stomach (belly), the thigh, or the upper arm, using an autoinjector (pen).
Rybelsus (semaglutide) oral tablets
- Rybelsus is used to treat type 2 diabetes in adults to help control blood sugar levels
- Oral tablet taken daily
- Semaglutide tablets should be used in addition to a reduced-calorie diet and increased physical activity.
Also, see Wegovy vs Ozempic: Which is right for you?
What is the difference between Ozempic, Wegovy, and Rybelsus?
| Brand of semaglutide | Ozempic | Wegovy | Rybelsus |
| Form | subcutaneous injection | subcutaneous injection | tablet |
| Strength | 0.25 mg or 0.5 mg dose pen, 1 mg dose pen, 2mg dose pen. | 0.25 mg dose pen, 0.5 mg dose pen, 1 mg dose pen, 1.7 mg dose pen, 2.4 mg dose pen | R1 formulation: 3 mg tablet, 7 mg tablet, and 14 mg tablet
R2 formulation: 1.5 mg, 4 mg, and 9 mg tablet |
| Dose | weekly | weekly | daily |
| Uses | Type 2 diabetic adults to help control blood sugar levels, when used together with diet and exercise.
Reduce the risk of major cardiac events in patients type 2 diabetes and cardiovascular disease Reduce the risk of kidney function decline, kidney failure, and death due to cardiovascular disease, in adults with chronic kidney disease (CKD) and type 2 diabetes. |
Weight loss and weight management for patients aged 12 years and older with obesity.
Reduce major cardiovascular event risks in adults with type 2 diabetes with known heart disease. It is used together with diet and exercise. |
Type 2 diabetic adults to help control blood sugar levels when used together with diet and exercise. |
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